Tirzepatide is a dual GIP and GLP-1 receptor agonist used for the treatment of type 2 diabetes mellitus. It is administered as a once-weekly subcutaneous injection.
This compounded version is by Empower Pharmacy and the full details provided by the company can be found at here. Empower has been registered as Human Drug Compounding Outsourcing Facilities Under Section 503B of the Federal Food, Drug, and Cosmetic Act (FD&C Act) since 2016 and, at the time of this writing, was last inspected without concern on 8/28/2024.
The FDA website can be foundhere.
Tirzepatide functions as both a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist. This dual action helps in:
Improving glycemic control
Reducing body weight
Niacinamide, also known as nicotinamide, is a form of vitamin B3. In the context of tirzepatide injections, it serves several important functions:
Stabilizer: It helps maintain the stability of the tirzepatide molecule in the solution.
Absorption enhancer: Niacinamide may improve the absorption of tirzepatide when injected subcutaneously.
Potential metabolic benefits: As a vitamin B3 derivative, niacinamide itself has some metabolic effects that may complement tirzepatide's action.
The addition of niacinamide to tirzepatide injections is part of the compounding process and may contribute to the overall efficacy and stability of the medication.
Clinical studies have shown that tirzepatide:
Significantly reduces hemoglobin A1C levels compared to placebo
Promotes weight loss in a dose-dependent manner
May have potential benefits for non-alcoholic fatty liver disease (NAFLD) patients
Tirzepatide is typically administered as follows:
Once-weekly subcutaneous injection
Available in various strengths (e.g., 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg)
Dose is usually titrated over time to reach the target dose
Common side effects may include:
Nausea
Diarrhea
Decreased appetite
Vomiting
Constipation
Abdominal pain
Tirzepatide should be used with caution in patients with:
History of pancreatitis
Severe gastrointestinal disease
Diabetic retinopathy
Pregnancy: Tirzepatide should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus. There is limited data on the use of tirzepatide in pregnant women.
Breastfeeding: It is not known whether tirzepatide is excreted in human milk. A risk to the newborns/infants cannot be excluded. A decision must be made whether to discontinue breastfeeding or to discontinue/abstain from tirzepatide therapy, taking into account the benefit of breastfeeding for the child and the benefit of therapy for the woman.
Women of childbearing potential should use effective contraception while using tirzepatide.
Tirzepatide should be stored properly:
Refrigerate at 2°C to 8°C (36°F to 46°F)
Do not freeze
Protect from light
Can be stored at room temperature for up to 21 days
Tirzepatide niacinamide injection is available as a compounded medication. It's important to note that compounded medications are not FDA-approved and should be used under the guidance of a healthcare professional.
Always consult with a healthcare provider before starting or changing any medication regimen. The information provided here is for educational purposes only and does not replace professional medical advice.
[1] Rosenstock, J., et al. (2021). Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial. The Lancet, 398(10295), 143-155.
[2] Frías, J. P., et al. (2021). Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes. New England Journal of Medicine, 385(6), 503-515.
[3] Min, T., & Bain, S. C. (2021). The Role of Tirzepatide, Dual GIP and GLP-1 Receptor Agonist, in the Management of Type 2 Diabetes: The SURPASS Clinical Trials. Diabetes Therapy, 12(1), 143-157.
[4] Empower Pharmacy. (2024). Tirzepatide Niacinamide Injection. Retrieved from https://www.empowerpharmacy.com/compounding-pharmacy/tirzepatide-niacinamide-injection/
[5] U.S. Food and Drug Administration. (2024). Registered Outsourcing Facilities. Retrieved from https://www.fda.gov/drugs/human-drug-compounding/registered-outsourcing-facilities
Accurate dosing of injectable medications is paramount to yoursafety and treatment success. At Hush Medical Spa, your well-being is always our highest priority.
Each syringe is filled by a fully licensed and medically trained provider, following strict protocols to ensure precision and consistency. We take every measure to ensure you receive exactly what has been prescribed — no more, no less — with the quality and care you deserve.
You can feel confident knowing that your treatment has beenprepared with expert hands and your best interests at heart
Your syringe may display one or both of the following scales:
· “U” (Units) — typically used for insulin syringes
· “mL” (milliliters) — the standard metric measurement,also equivalent to cc (cubic centimeters)
For reference:
10 Units (10U) = 0.1 mL = 0.1 cc
At Hush Medical Spa, we prepare your syringe with precision. Aslight overfill of 1 Unit (0.01 mL) is includedintentionally. This small buffer allows you to expel any air bubbles beforeinjection without compromising your prescribed dose.
This meticulous approach ensures both accuracy and safety in yourself-administered care.
Drugs.comis a trusted, U.S.-based resource providing accurate, up-to-date information on prescription and over-the-counter medications, supplements, and drug interactions. It’s designed for both patients and healthcare professionals, offering easy-to-understand explanations, side effect profiles, and safety warnings.
At Hush Medical Spa, we recommend Drugs.com for clients who want to explore more about the medications we may discuss during your visit — including Botox®, fillers, or supplements you’re currently taking.
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It’s a trusted resource for clients who want a deeper understanding of health topics, including skin conditions, injectables, hormone therapy, and more. All content is reviewed by medical experts and updated regularly.
MedlinePlus is a health information website maintained by the U.S. National Library of Medicine. It provides reliable, evidence-based information on a wide range of medical conditions, medications, and wellness topics — without advertising or bias.
It’s a trusted resource for clients who want a deeper understanding of health topics, including skin conditions, injectables, hormone therapy, and more. All content is reviewed by medical experts and updated regularly.
