tirzepatide

Tirzepatide 20mg/Pyridoxine 50mg

Tirzepatide is a once-weekly, subcutaneous injectable medication compounded by Beaker Pharmacy to support glycemic control and promote healthy, sustained weight loss. Each mL of this compounded formulation contains:

  • Tirzepatide 20mg/mL
  • Niacinamide (Vitamin B3) 50mg/mL

This therapy is dispensed through a licensed compounding pharmacy that operates under FDA oversight and in accordance with Section 503B of the Federal Food, Drug, and Cosmetic Act. Beaker Pharmacy is compliant with current good manufacturing practices (cGMP) and maintains rigorous quality assurance standards.

Mechanism of Action

Tirzepatide is a dual receptor agonist targeting:

  • Glucose-Dependent Insulinotropic Polypeptide (GIP) receptors
  • Glucagon-Like Peptide-1 (GLP-1) receptors

This dual mechanism:

  • Enhances glucose-dependent insulin secretion
  • Suppresses glucagon secretion during hyperglycemia
  • Slows gastric emptying
  • Reduces appetite and promotes satiety
  • Contributes to meaningful weight loss and improved metabolic markers

Role of Niacinamide (Vitamin B3)

In this compounded formulation, niacinamide acts as:

  • A stabilizer to preserve the integrity of tirzepatide in solution
  • An absorption enhancer to support more consistent uptake
  • A metabolic co-factor with potential synergistic benefits for energy production, mitochondrial function, and lipid regulation

Clinical Efficacy

Evidence from the SURPASS trial series and peer-reviewed literature has demonstrated that tirzepatide:

  • Significantly lowers hemoglobin A1C in patients with type 2 diabetes
  • Induces dose-dependent weight loss in non-diabetic populations
  • Shows promise in managing non-alcoholic fatty liver disease (NAFLD)

Dosing and Administration

  • Route: Subcutaneous injection (abdomen, thigh, or upper arm)
  • Frequency: Once weekly
  • Dosing Range: Initiated at lower doses (e.g., 2.5mg) and titrated up (up to 15mg weekly)
  • Custom dosing is determined by your Hush provider based on your tolerance, goals, and clinical response

Side Effects

Common:

  • Nausea
  • Vomiting
  • Diarrhea or constipation
  • Reduced appetite
  • Fatigue
  • Injection site irritation

Rare but Serious:

  • Pancreatitis
  • Gallbladder disease
  • Kidney function changes
  • Risk of thyroid tumors (in preclinical models only)

Precautions

Tirzepatide should be used with caution in clients with:

  • History of pancreatitis
  • Significant gastrointestinal disorders (e.g., gastroparesis)
  • Active diabetic retinopathy
  • Pregnancy or breastfeeding (not recommended)
  • Known medullary thyroid carcinoma or MEN2 syndrome (contraindicated)

Use in Pregnancy and Lactation

  • Pregnancy: Not recommended unless potential benefit justifies the risk.
  • Breastfeeding: Unknown if excreted in breast milk; use with caution.
  • Women of childbearing potential should use effective contraception during treatment.

Storage and Handling

  • Refrigerate at 2°C to 8°C (36°F to 46°F)
  • Do not freeze
  • Protect from light
  • May be stored at room temperature (up to 77°F) for up to 21 days if refrigeration is unavailable

Compounding Statement

This formulation is a compounded medication and therefore not FDA-approved. It is prepared by Beaker Pharmacy, an FDA-registered 503B outsourcing facility with cGMP compliance and quality oversight. Use only under the direction of a licensed healthcare provider.

References

  1. Rosenstock J, et al. The Lancet. 2021.
  2. Frías JP, et al. NEJM. 2021.
  3. Min T, Bain SC. Diabetes Therapy. 2021.
  4. Empower Pharmacy. Tirzepatide Niacinamide Injection (2024).
  5. FDA.gov. Registered Outsourcing Facilities. 2024.

Syringe Fill By Dose

Accurate dosing of injectable medications is paramount to yoursafety and treatment success. At Hush Medical Spa, your well-being is always our highest priority.

Each syringe is filled by a fully licensed and medically trained provider, following strict protocols to ensure precision and consistency. We take every measure to ensure you receive exactly what has been prescribed — no more, no less — with the quality and care you deserve.

You can feel confident knowing that your treatment has beenprepared with expert hands and your best interests at heart

Your syringe may display one or both of the following scales:

·       “U” (Units) — typically used for insulin syringes

·       “mL” (milliliters) — the standard metric measurement,also equivalent to cc (cubic centimeters)

For reference:

10 Units (10U) = 0.1 mL = 0.1 cc

At Hush Medical Spa, we prepare your syringe with precision. Aslight overfill of 1 Unit (0.01 mL) is includedintentionally. This small buffer allows you to expel any air bubbles beforeinjection without compromising your prescribed dose.

This meticulous approach ensures both accuracy and safety in yourself-administered care.

Drugs.com

Drugs.comis a trusted, U.S.-based resource providing accurate, up-to-date information on prescription and over-the-counter medications, supplements, and drug interactions. It’s designed for both patients and healthcare professionals, offering easy-to-understand explanations, side effect profiles, and safety warnings.

At Hush Medical Spa, we recommend Drugs.com for clients who want to explore more about the medications we may discuss during your visit — including Botox®, fillers, or supplements you’re currently taking.

MedlinePlus is a health information website maintained by the U.S. National Library of Medicine. It provides reliable, evidence-based information on a wide range of medical conditions, medications, and wellness topics — without advertising or bias.

It’s a trusted resource for clients who want a deeper understanding of health topics, including skin conditions, injectables, hormone therapy, and more. All content is reviewed by medical experts and updated regularly.

Search Drugs.com for
tirzepatide

MedlinePlus.gov

MedlinePlus is a health information website maintained by the U.S. National Library of Medicine. It provides reliable, evidence-based information on a wide range of medical conditions, medications, and wellness topics — without advertising or bias.

It’s a trusted resource for clients who want a deeper understanding of health topics, including skin conditions, injectables, hormone therapy, and more. All content is reviewed by medical experts and updated regularly.

Search Medline.gov for
tirzepatide

Mailing Address

Lazar Medical Group, PC
400 Market Street
Suite 5
Williamsport, PA 17701
Office: (570) 993-5507
Fax: (570) 431-6643

Providers

Michael J Lazar, MD
NPI: 1962469650
Phone: (717) 370-1716
Krista Lazar, MD in scrubs
Krista A. Lazar, MD
NPI: 1932270204
Phone: (717) 497-4778
Pharmacy:
Beaker
This reference is provided by Hush Medical Spa for patient education. It does not replace medical advice. Always follow the guidance of your prescribing provider.