Metformin HCL ER 500Mg

Metformin HCl ER 500 mg

Extended-Release Oral Tablet

Overview

Metformin Hydrochloride Extended Release (ER) 500 mg is a prescription medication primarily used to manage type 2 diabetes mellitus by improving insulin sensitivity and lowering blood glucose levels. Its mechanism of action centers on reducing hepatic glucose production, enhancing peripheral glucose uptake, and decreasing intestinal absorption of glucose.

As an extended-release formulation, Metformin ER provides gentler gastrointestinal tolerability compared to the immediate-release form, allowing for more consistent blood levels and once-daily dosing.

Medical Uses

  • Type 2 Diabetes Mellitus
    • Improves insulin sensitivity
    • Decreases hepatic gluconeogenesis
    • Enhances glycemic control without causing hypoglycemia
    • Often used as first-line pharmacologic therapy
  • Polycystic Ovary Syndrome (PCOS)
    • Helps regulate menstrual cycles
    • Improves insulin resistance
    • May support fertility and ovulation
  • Prediabetes / Metabolic Syndrome
    • Slows or prevents progression to type 2 diabetes
    • Supports improved lipid profile and weight control

Use in Weight Loss and Wellness

At Hush Medical Spa, Metformin ER 500 mg may be thoughtfully incorporated into personalized wellness and weight optimization protocols, particularly for clients with:

  • Insulin resistance
  • Visceral fat accumulation
  • Cravings and appetite dysregulation
  • Suboptimal metabolic markers

Benefits in a Wellness Context:

  • Supports Fat Loss
  • By improving the body’s ability to use insulin effectively, Metformin reduces circulating insulin levels, which can decrease fat storage and promote lipolysis, particularly around the abdomen.
  • Appetite Regulation
  • Some patients experience a modest reduction in appetite, supporting behavioral efforts toward calorie control.
  • Hormonal Balance
  • Particularly in women with PCOS or estrogen dominance, Metformin can help rebalance hormones that contribute to fat retention and inflammation.
  • Enhanced Mitochondrial Function
  • Research suggests that Metformin may support cellular energy regulation, with potential anti-aging benefits due to its impact on AMPK (adenosine monophosphate-activated protein kinase) pathways.

Dosing and Administration

  • Starting Dose:
  • 500 mg once daily with the evening meal
  • Titration:
  • May be gradually increased every 1–2 weeks based on tolerability and clinical goals (up to 2000 mg/day in divided doses)
  • Formulation:
  • Extended-release for improved gastrointestinal tolerability and stable blood levels

Side Effects and Precautions

Common side effects (especially when starting):

  • Mild gastrointestinal upset (nausea, diarrhea, gas)
  • Metallic taste
  • Fatigue or mild dizziness

Serious but rare risks:

  • Lactic acidosis (very rare; risk increased in renal impairment)
  • Vitamin B12 deficiency with long-term use
Clients undergoing Hush-prescribed Metformin therapy will have appropriate lab monitoring and individualized dosing to mitigate side effects and optimize benefits.

Contraindications

Metformin is not appropriate for individuals with:

  • Severe renal impairment (eGFR < 30 mL/min/1.73m²)
  • Active liver disease
  • Alcohol abuse
  • Uncontrolled heart failure or acute illness causing dehydration or hypoxia

Integrative Approach at Hush

Our team may recommend Metformin ER 500 mg as part of a broader wellness plan, including:

  • Bioidentical hormone therapy
  • Nutraceutical support (berberine, inositol, chromium)
  • Peptide therapy (GLP-1s)
  • Nutrition & movement guidance
  • Advanced lab testing (fasting insulin, HbA1c, lipids, inflammatory markers)

All interventions are overseen by experienced medical professionals with decades of combined expertise in hormonal health, metabolism, and aesthetics.

Empowered Wellness

At Hush Medical Spa, our use of therapeutic tools like Metformin is always intentional, refined, and personalized. Whether you’re navigating metabolic shifts, hormonal transitions, or optimizing for long-term vitality, we are here to help you reclaim confidence, clarity, and control over your body.

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Syringe Fill By Dose

Accurate dosing of injectable medications is paramount to yoursafety and treatment success. At Hush Medical Spa, your well-being is always our highest priority.

Each syringe is filled by a fully licensed and medically trained provider, following strict protocols to ensure precision and consistency. We take every measure to ensure you receive exactly what has been prescribed — no more, no less — with the quality and care you deserve.

You can feel confident knowing that your treatment has beenprepared with expert hands and your best interests at heart

Your syringe may display one or both of the following scales:

·       “U” (Units) — typically used for insulin syringes

·       “mL” (milliliters) — the standard metric measurement,also equivalent to cc (cubic centimeters)

For reference:

10 Units (10U) = 0.1 mL = 0.1 cc

At Hush Medical Spa, we prepare your syringe with precision. Aslight overfill of 1 Unit (0.01 mL) is includedintentionally. This small buffer allows you to expel any air bubbles beforeinjection without compromising your prescribed dose.

This meticulous approach ensures both accuracy and safety in yourself-administered care.

Drugs.com

Drugs.comis a trusted, U.S.-based resource providing accurate, up-to-date information on prescription and over-the-counter medications, supplements, and drug interactions. It’s designed for both patients and healthcare professionals, offering easy-to-understand explanations, side effect profiles, and safety warnings.

At Hush Medical Spa, we recommend Drugs.com for clients who want to explore more about the medications we may discuss during your visit — including Botox®, fillers, or supplements you’re currently taking.

MedlinePlus is a health information website maintained by the U.S. National Library of Medicine. It provides reliable, evidence-based information on a wide range of medical conditions, medications, and wellness topics — without advertising or bias.

It’s a trusted resource for clients who want a deeper understanding of health topics, including skin conditions, injectables, hormone therapy, and more. All content is reviewed by medical experts and updated regularly.

Search Drugs.com for
Metformin HCL ER 500Mg

MedlinePlus.gov

MedlinePlus is a health information website maintained by the U.S. National Library of Medicine. It provides reliable, evidence-based information on a wide range of medical conditions, medications, and wellness topics — without advertising or bias.

It’s a trusted resource for clients who want a deeper understanding of health topics, including skin conditions, injectables, hormone therapy, and more. All content is reviewed by medical experts and updated regularly.

Search Medline.gov for
Metformin HCL ER 500Mg

Mailing Address

Lazar Medical Group, PC
400 Market Street
Suite 5
Williamsport, PA 17701
Office: (570) 993-5507
Fax: (570) 431-6643

Providers

Michael J Lazar, MD
NPI: 1962469650
Phone: (717) 370-1716
Krista Lazar, MD in scrubs
Krista A. Lazar, MD
NPI: 1932270204
Phone: (717) 497-4778
This reference is provided by Hush Medical Spa for patient education. It does not replace medical advice. Always follow the guidance of your prescribing provider.